Enables SH3 domain binding activity. Predicted to be involved in regulation of endocytosis. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RUFY2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RUFY2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RUFY2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:68,208,472–68,208,961 | 198.6 kb | Distal (>10kb) Multiome | 254 | |
| chr10:68,231,028–68,232,253 | 175.8 kb | Distal (>10kb) Multiome | 654 | |
| chr10:68,271,165–68,272,025 | 135.7 kb | Distal (>10kb) Multiome | 177 | |
| chr10:68,331,343–68,333,064 | 74.3 kb | Distal (>10kb) Multiome | 1174 | |
| chr10:68,406,245–68,407,662 | 26 bp | At TSS Multiome | 898 | |
| chr10:68,471,473–68,472,528 | 64.7 kb | Distal (>10kb) Multiome | 831 | |
| chr10:68,527,011–68,528,012 | 120.3 kb | Distal (>10kb) Multiome | 912 | |
| chr10:68,559,963–68,561,065 | 153.1 kb | Distal (>10kb) Multiome | 777 | |
| chr10:68,600,036–68,600,760 | 193.2 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the RUFY2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.