Enables signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; corpus callosum development; and negative regulation of neuron projection development. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RTN4RL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RTN4RL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RTN4RL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,277,829–57,278,561 | 182.4 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,310,924–57,312,111 | 149.0 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,323,847–57,325,914 | 135.5 kb | Distal (>10kb) Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 124.7 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 114.7 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 110.6 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,426,113–57,427,448 | 33.4 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 3.1 kb | Proximal (<10kb) Multiome | 458 | |
| chr11:57,458,156–57,459,580 | 946 bp | At TSS | 531 | |
| chr11:57,460,127–57,461,576 | 857 bp | At TSS Multiome | 418 | |
| chr11:57,464,333–57,464,559 | 3.8 kb | Proximal (<10kb) | 46 | |
| chr11:57,482,336–57,483,518 | 22.6 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 33.1 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 39.3 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 53.9 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 70.4 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 107.6 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 137.6 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 179.0 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 184.4 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,656,843–57,658,231 | 197.1 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 207.3 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 251.7 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 280.9 kb | Distal (>10kb) Multiome | 973 |
Genomic view of the RTN4RL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.