Enables transcription coactivator activity. Involved in cellular response to virus; positive regulation of apoptotic process; and positive regulation of transcription by RNA polymerase II. Located in chromosome; granular component; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RRP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:42,234,400–42,235,305 | 1424.7 kb | Distal (>10kb) Multiome HiCAR | 427 | |
| chr21:42,892,360–42,893,974 | 766.4 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr21:43,659,125–43,659,916 | 23 bp | At TSS Multiome | 989 | |
| chr21:43,718,478–43,719,766 | 59.6 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,728,503–43,729,213 | 69.3 kb | Distal (>10kb) Multiome | 905 | |
| chr21:43,740,577–43,741,104 | 81.3 kb | Distal (>10kb) Multiome | 198 | |
| chr21:43,775,786–43,776,893 | 116.9 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,788,879–43,790,067 | 129.9 kb | Distal (>10kb) Multiome | 930 | |
| chr21:43,864,215–43,864,709 | 204.8 kb | Distal (>10kb) Multiome | 538 | |
| chr21:43,865,135–43,865,798 | 205.9 kb | Distal (>10kb) Multiome | 333 | |
| chr21:43,883,997–43,884,476 | 224.7 kb | Distal (>10kb) Multiome | 418 | |
| chr21:43,921,393–43,922,764 | 262.4 kb | Distal (>10kb) Multiome | 622 |
Genomic view of the RRP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.