This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RRP15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRP15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRP15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:218,163,871–218,166,014 | 120.6 kb | Distal (>10kb) Multiome | 548 | |
| chr1:218,178,933–218,179,899 | 105.8 kb | Distal (>10kb) Multiome | 109 | |
| chr1:218,277,960–218,278,740 | 6.6 kb | Proximal (<10kb) | 36 | |
| chr1:218,284,474–218,285,788 | 109 bp | At TSS Multiome | 1053 | |
| chr1:218,344,881–218,346,381 | 60.5 kb | Distal (>10kb) Multiome | 644 | |
| chr1:219,660,416–219,661,624 | 1375.7 kb | Distal (>10kb) Multiome HiCAR | 431 | |
| chr1:219,834,079–219,834,880 | 1549.3 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr1:219,839,143–219,840,267 | 1554.5 kb | Distal (>10kb) Multiome HiCAR | 246 |
Genomic view of the RRP15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.