This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for RRM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:3,796,972–3,798,333 | 297.1 kb | Distal (>10kb) Multiome | 985 | |
| chr11:3,807,708–3,808,953 | 286.5 kb | Distal (>10kb) Multiome | 598 | |
| chr11:3,824,581–3,825,191 | 270.0 kb | Distal (>10kb) Multiome | 332 | |
| chr11:3,840,339–3,841,901 | 253.8 kb | Distal (>10kb) Multiome HiCAR | 853 | |
| chr11:3,854,400–3,856,473 | 239.7 kb | Distal (>10kb) Multiome HiCAR | 929 | |
| chr11:4,094,080–4,095,334 | 131 bp | At TSS Multiome | 925 | |
| chr11:4,186,986–4,188,050 | 92.8 kb | Distal (>10kb) Multiome | 624 | |
| chr11:4,393,027–4,394,247 | 298.8 kb | Distal (>10kb) Multiome | 516 |
Genomic view of the RRM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.