RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for RRAGD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRAGD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRAGD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:89,117,325–89,118,595 | 294.1 kb | Distal (>10kb) Multiome | 482 | |
| chr6:89,145,740–89,146,828 | 265.7 kb | Distal (>10kb) Multiome | 853 | |
| chr6:89,242,677–89,243,345 | 169.0 kb | Distal (>10kb) Multiome | 160 | |
| chr6:89,311,590–89,312,158 | 100.1 kb | Distal (>10kb) Multiome | 214 | |
| chr6:89,352,138–89,353,410 | 59.3 kb | Distal (>10kb) Multiome | 882 | |
| chr6:89,404,392–89,404,922 | 7.1 kb | Proximal (<10kb) | 15 | |
| chr6:89,411,134–89,412,806 | 254 bp | At TSS Multiome | 540 | |
| chr6:89,432,777–89,434,173 | 21.1 kb | Distal (>10kb) Multiome | 524 | |
| chr6:89,483,120–89,483,667 | 71.4 kb | Distal (>10kb) Multiome | 199 | |
| chr6:89,638,049–89,639,180 | 226.6 kb | Distal (>10kb) Multiome | 783 |
Genomic view of the RRAGD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.