This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for RPS6KB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:59,619,053–59,620,313 | 273.5 kb | Distal (>10kb) Multiome | 1183 | |
| chr17:59,707,078–59,708,143 | 185.5 kb | Distal (>10kb) Multiome | 963 | |
| chr17:59,837,406–59,838,036 | 55.4 kb | Distal (>10kb) Multiome | 865 | |
| chr17:59,892,295–59,893,854 | 34 bp | At TSS Multiome | 992 | |
| chr17:59,964,460–59,965,228 | 71.7 kb | Distal (>10kb) Multiome | 834 | |
| chr17:60,037,145–60,037,598 | 144.2 kb | Distal (>10kb) Multiome | 592 | |
| chr17:60,078,377–60,079,189 | 185.7 kb | Distal (>10kb) Multiome | 765 | |
| chr17:60,135,208–60,135,905 | 242.6 kb | Distal (>10kb) Multiome | 832 | |
| chr17:60,139,659–60,140,250 | 246.8 kb | Distal (>10kb) Multiome | 847 | |
| chr17:60,142,132–60,142,546 | 249.2 kb | Distal (>10kb) Multiome | 250 | |
| chr17:60,142,949–60,143,382 | 250.0 kb | Distal (>10kb) Multiome | 395 |
Genomic view of the RPS6KB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.