Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RPP40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPP40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPP40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:4,774,740–4,777,263 | 227.9 kb | Distal (>10kb) Multiome | 707 | |
| chr6:4,925,466–4,925,943 | 78.3 kb | Distal (>10kb) Multiome | 71 | |
| chr6:5,003,235–5,004,614 | 183 bp | At TSS Multiome | 925 | |
| chr6:5,025,821–5,026,808 | 22.3 kb | Distal (>10kb) Multiome | 434 | |
| chr6:5,036,286–5,036,731 | 32.4 kb | Distal (>10kb) Multiome | 261 | |
| chr6:5,084,296–5,086,827 | 82.1 kb | Distal (>10kb) Multiome | 640 | |
| chr6:5,260,007–5,261,755 | 257.1 kb | Distal (>10kb) Multiome | 931 |
Genomic view of the RPP40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.