This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPP25L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPP25L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPP25L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,328,711–34,329,961 | 282.7 kb | Distal (>10kb) Multiome | 768 | |
| chr9:34,363,597–34,364,212 | 248.2 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,374,953–34,375,681 | 236.9 kb | Distal (>10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 235.1 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 231.2 kb | Distal (>10kb) Multiome | 763 | |
| chr9:34,456,881–34,459,235 | 153.4 kb | Distal (>10kb) Multiome | 704 | |
| chr9:34,522,211–34,523,972 | 88.9 kb | Distal (>10kb) Multiome HiCAR | 473 | |
| chr9:34,577,374–34,578,752 | 34.1 kb | Distal (>10kb) Multiome | 204 | |
| chr9:34,589,298–34,591,068 | 22.3 kb | Distal (>10kb) Multiome | 258 | |
| chr9:34,591,283–34,592,013 | 20.2 kb | Distal (>10kb) Multiome | 368 | |
| chr9:34,603,742–34,603,948 | 8.1 kb | Proximal (<10kb) | 183 | |
| chr9:34,611,663–34,612,738 | 69 bp | At TSS Multiome | 680 | |
| chr9:34,612,834–34,613,263 | 1.0 kb | Proximal (<10kb) Multiome | 343 | |
| chr9:34,620,108–34,620,704 | 8.4 kb | Proximal (<10kb) Multiome | 467 | |
| chr9:34,628,770–34,629,308 | 17.0 kb | Distal (>10kb) Multiome HiCAR | 216 | |
| chr9:34,637,123–34,638,475 | 25.8 kb | Distal (>10kb) Multiome HiCAR | 872 | |
| chr9:34,646,247–34,647,338 | 34.6 kb | Distal (>10kb) Multiome | 857 | |
| chr9:34,651,771–34,652,431 | 40.0 kb | Distal (>10kb) Multiome | 669 | |
| chr9:34,664,346–34,666,446 | 53.5 kb | Distal (>10kb) Multiome | 707 | |
| chr9:34,674,895–34,675,574 | 63.1 kb | Distal (>10kb) Multiome | 372 | |
| chr9:34,701,127–34,701,863 | 89.4 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the RPP25L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.