This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,426,214–128,426,887 | 224.3 kb | Distal (>10kb) Multiome | 505 | |
| chr3:128,432,305–128,433,430 | 217.7 kb | Distal (>10kb) Multiome | 265 | |
| chr3:128,456,900–128,457,416 | 193.6 kb | Distal (>10kb) Multiome | 127 | |
| chr3:128,487,682–128,488,679 | 162.8 kb | Distal (>10kb) Multiome | 710 | |
| chr3:128,489,907–128,490,591 | 160.6 kb | Distal (>10kb) Multiome | 413 | |
| chr3:128,492,255–128,493,190 | 158.0 kb | Distal (>10kb) Multiome | 270 | |
| chr3:128,497,309–128,498,144 | 152.9 kb | Distal (>10kb) Multiome | 464 | |
| chr3:128,581,519–128,582,200 | 69.0 kb | Distal (>10kb) Multiome | 16 | |
| chr3:128,607,947–128,608,800 | 42.4 kb | Distal (>10kb) Multiome | 376 | |
| chr3:128,617,357–128,618,496 | 33.0 kb | Distal (>10kb) Multiome | 735 | |
| chr3:128,650,142–128,651,178 | 25 bp | At TSS Multiome | 772 | |
| chr3:128,653,061–128,654,283 | 3.0 kb | Proximal (<10kb) Multiome | 55 | |
| chr3:128,675,353–128,676,166 | 25.1 kb | Distal (>10kb) Multiome | 103 | |
| chr3:128,680,397–128,681,422 | 30.1 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:128,698,248–128,698,988 | 47.8 kb | Distal (>10kb) Multiome | 239 | |
| chr3:128,725,886–128,726,915 | 75.3 kb | Distal (>10kb) Multiome | 900 | |
| chr3:128,832,889–128,833,369 | 182.4 kb | Distal (>10kb) Multiome | 38 | |
| chr3:128,845,614–128,846,390 | 195.2 kb | Distal (>10kb) Multiome | 538 | |
| chr3:128,878,828–128,880,293 | 228.7 kb | Distal (>10kb) Multiome | 1016 |
Genomic view of the RPN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.