Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPLP0. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPLP0 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPLP0, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:119,988,471–119,990,364 | 211.1 kb | Distal (>10kb) Multiome | 892 | |
| chr12:120,086,807–120,087,619 | 113.9 kb | Distal (>10kb) Multiome | 957 | |
| chr12:120,093,667–120,094,287 | 107.1 kb | Distal (>10kb) Multiome | 172 | |
| chr12:120,116,125–120,117,765 | 84.2 kb | Distal (>10kb) Multiome | 903 | |
| chr12:120,194,328–120,196,208 | 6.3 kb | Proximal (<10kb) Multiome | 1032 | |
| chr12:120,200,671–120,201,921 | 146 bp | At TSS Multiome | 1006 | |
| chr12:120,228,170–120,231,900 | 27.5 kb | Distal (>10kb) Multiome HiCAR | 1050 | |
| chr12:120,265,150–120,266,362 | 64.7 kb | Distal (>10kb) Multiome HiCAR | 617 | |
| chr12:120,290,301–120,293,526 | 92.1 kb | Distal (>10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | 101.2 kb | Distal (>10kb) Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 116.5 kb | Distal (>10kb) Multiome | 872 | |
| chr12:120,361,277–120,362,299 | 160.7 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 168.1 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 188.1 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 193.7 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 213.1 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 236.9 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 245.4 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 268.6 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 294.9 kb | Distal (>10kb) Multiome | 794 |
Genomic view of the RPLP0 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.