Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPL36. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL36 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL36, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:5,397,820–5,398,866 | 291.9 kb | Distal (>10kb) Multiome | 137 | |
| chr19:5,436,304–5,437,277 | 253.5 kb | Distal (>10kb) Multiome | 227 | |
| chr19:5,536,326–5,536,869 | 153.6 kb | Distal (>10kb) Multiome | 306 | |
| chr19:5,567,504–5,568,201 | 122.5 kb | Distal (>10kb) Multiome | 209 | |
| chr19:5,585,656–5,586,338 | 104.3 kb | Distal (>10kb) Multiome | 267 | |
| chr19:5,621,964–5,623,739 | 67.4 kb | Distal (>10kb) Multiome | 857 | |
| chr19:5,679,757–5,681,464 | 9.5 kb | Proximal (<10kb) Multiome | 884 | |
| chr19:5,686,329–5,687,994 | 3.3 kb | Proximal (<10kb) Multiome | 693 | |
| chr19:5,689,735–5,690,874 | 2 bp | At TSS Multiome | 960 | |
| chr19:5,719,717–5,721,174 | 30.1 kb | Distal (>10kb) Multiome | 985 | |
| chr19:5,790,527–5,791,509 | 100.6 kb | Distal (>10kb) Multiome | 965 | |
| chr19:5,803,750–5,806,128 | 114.9 kb | Distal (>10kb) Multiome | 858 | |
| chr19:5,826,528–5,829,726 | 137.8 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:5,903,474–5,905,358 | 214.3 kb | Distal (>10kb) Multiome | 1027 | |
| chr19:5,977,406–5,978,787 | 287.9 kb | Distal (>10kb) Multiome | 1028 |
Genomic view of the RPL36 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.