Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for RPL18A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL18A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL18A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:17,448,174–17,448,841 | 411.3 kb | Distal (>10kb) Multiome HiCAR | 392 | |
| chr19:17,468,858–17,470,905 | 389.8 kb | Distal (>10kb) Multiome HiCAR | 743 | |
| chr19:17,576,463–17,577,455 | 282.9 kb | Distal (>10kb) Multiome | 236 | |
| chr19:17,579,580–17,580,242 | 279.9 kb | Distal (>10kb) Multiome | 281 | |
| chr19:17,605,468–17,607,009 | 253.7 kb | Distal (>10kb) Multiome | 1030 | |
| chr19:17,686,280–17,688,656 | 173.1 kb | Distal (>10kb) Multiome | 586 | |
| chr19:17,719,144–17,719,957 | 140.4 kb | Distal (>10kb) Multiome | 585 | |
| chr19:17,747,227–17,748,170 | 112.3 kb | Distal (>10kb) Multiome | 503 | |
| chr19:17,762,487–17,762,985 | 97.2 kb | Distal (>10kb) Multiome | 199 | |
| chr19:17,778,112–17,778,869 | 81.5 kb | Distal (>10kb) Multiome | 311 | |
| chr19:17,794,880–17,795,385 | 64.8 kb | Distal (>10kb) Multiome | 465 | |
| chr19:17,829,926–17,831,824 | 29.0 kb | Distal (>10kb) Multiome | 466 | |
| chr19:17,841,205–17,843,221 | 17.8 kb | Distal (>10kb) Multiome | 545 | |
| chr19:17,847,546–17,848,187 | 12.2 kb | Distal (>10kb) Multiome | 437 | |
| chr19:17,855,644–17,855,880 | 4.0 kb | Proximal (<10kb) | 403 | |
| chr19:17,859,472–17,860,202 | 146 bp | At TSS Multiome | 822 | |
| chr19:17,873,769–17,874,763 | 14.3 kb | Distal (>10kb) Multiome | 303 | |
| chr19:17,931,700–17,932,248 | 72.0 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr19:17,932,373–17,933,607 | 72.9 kb | Distal (>10kb) Multiome HiCAR | 924 | |
| chr19:17,942,639–17,943,673 | 83.4 kb | Distal (>10kb) Multiome | 302 | |
| chr19:17,947,203–17,950,613 | 88.1 kb | Distal (>10kb) Multiome | 639 | |
| chr19:17,951,201–17,952,652 | 92.3 kb | Distal (>10kb) Multiome | 237 | |
| chr19:17,966,756–17,967,353 | 107.2 kb | Distal (>10kb) Multiome | 127 | |
| chr19:18,000,754–18,001,614 | 141.2 kb | Distal (>10kb) Multiome | 788 | |
| chr19:18,007,024–18,008,451 | 148.2 kb | Distal (>10kb) Multiome | 681 | |
| chr19:18,058,070–18,058,878 | 198.6 kb | Distal (>10kb) Multiome | 542 | |
| chr19:18,104,219–18,104,847 | 244.6 kb | Distal (>10kb) Multiome | 466 | |
| chr19:18,109,636–18,110,594 | 250.2 kb | Distal (>10kb) Multiome | 601 | |
| chr19:18,117,556–18,118,528 | 258.0 kb | Distal (>10kb) Multiome | 550 | |
| chr19:18,152,230–18,153,823 | 293.0 kb | Distal (>10kb) Multiome | 809 |
Genomic view of the RPL18A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.