Transcription factors with Perturb-seq knockdown data for RORA-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RORA-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RORA-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:60,397,071–60,398,286 | 81.2 kb | Distal (>10kb) Multiome | 627 | |
| chr15:60,398,426–60,398,937 | 80.5 kb | Distal (>10kb) Multiome | 531 | |
| chr15:60,478,648–60,479,679 | 75 bp | At TSS Multiome | 975 | |
| chr15:60,591,104–60,593,374 | 113.5 kb | Distal (>10kb) Multiome | 802 | |
| chr15:60,614,824–60,615,950 | 136.2 kb | Distal (>10kb) Multiome | 252 |
Genomic view of the RORA-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.