Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U5 snRNP. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNU5A-1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNU5A-1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNU5A-1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:65,286,029–65,287,330 | 8.7 kb | Proximal (<10kb) | 919 | |
| chr15:65,289,512–65,289,739 | 6.3 kb | Proximal (<10kb) | 28 | |
| chr15:65,295,595–65,297,682 | at TSS | At TSS | 1039 | |
| chr15:65,297,790–65,298,201 | 1.7 kb | Proximal (<10kb) | 336 | |
| chr15:65,299,879–65,301,676 | 3.8 kb | Proximal (<10kb) | 464 | |
| chr15:65,303,709–65,305,825 | 7.7 kb | Proximal (<10kb) | 1230 |
Genomic view of the RNU5A-1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.