RNPEP
arginyl aminopeptidase | APB

Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-7 DE-7.2
Biological processes 21 terms
aminopeptidase activity (GO:0004177)aminopeptidase activity (GO:0004177)aminopeptidase activity (GO:0004177)epoxide hydrolase activity (GO:0004301)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)metalloaminopeptidase activity (GO:0070006)metalloaminopeptidase activity (GO:0070006)metalloexopeptidase activity (GO:0008235)metallopeptidase activity (GO:0008237)plasma membrane (GO:0005886)plasma membrane (GO:0005886)proteolysis (GO:0006508)proteolysis (GO:0006508)proteolysis (GO:0006508)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)
Expression (TPM)
RNPEP — as a Regulated Gene

TFs regulating RNPEP 0 TFs

Transcription factors with Perturb-seq knockdown data for RNPEP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNPEP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RNPEP

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNPEP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:201,709,409–201,709,946 273.3 kb Distal (>10kb) Multiome 258
chr1:201,739,028–201,740,430 243.2 kb Distal (>10kb) Multiome 287
chr1:201,828,821–201,829,863 153.7 kb Distal (>10kb) Multiome 821
chr1:201,888,189–201,889,202 94.1 kb Distal (>10kb) Multiome HiCAR 335
chr1:201,895,782–201,896,239 86.9 kb Distal (>10kb) Multiome HiCAR 606
chr1:201,941,439–201,942,399 41.0 kb Distal (>10kb) Multiome 508
chr1:201,946,301–201,946,923 36.4 kb Distal (>10kb) Multiome 290
chr1:201,955,139–201,955,899 27.5 kb Distal (>10kb) Multiome 881
chr1:201,982,248–201,983,657 355 bp At TSS Multiome 875
chr1:202,007,961–202,008,615 25.3 kb Distal (>10kb) Multiome 368
chr1:202,009,428–202,011,367 27.6 kb Distal (>10kb) Multiome 761
chr1:202,075,813–202,076,531 93.2 kb Distal (>10kb) Multiome 418
chr1:202,101,336–202,102,103 118.9 kb Distal (>10kb) Multiome HiCAR 173
chr1:202,105,597–202,106,270 123.0 kb Distal (>10kb) Multiome HiCAR 376
chr1:202,135,239–202,135,691 152.4 kb Distal (>10kb) Multiome HiCAR 193
chr1:202,143,721–202,144,890 161.0 kb Distal (>10kb) Multiome 589
chr1:202,184,705–202,185,268 202.0 kb Distal (>10kb) Multiome 258
chr1:202,214,010–202,214,579 231.4 kb Distal (>10kb) Multiome 215
chr1:202,235,967–202,236,655 253.5 kb Distal (>10kb) Multiome 460
chr1:202,237,030–202,237,425 254.4 kb Distal (>10kb) Multiome 305

Genome Browser

Genomic view of the RNPEP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:201,699,409 – 202,247,425
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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