Enables inorganic triphosphate phosphatase activity and mRNA guanylyltransferase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNGTT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNGTT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNGTT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:88,724,843–88,726,747 | 238.2 kb | Distal (>10kb) Multiome | 286 | |
| chr6:88,730,304–88,731,106 | 232.9 kb | Distal (>10kb) Multiome | 282 | |
| chr6:88,963,119–88,964,135 | 68 bp | At TSS Multiome | 826 | |
| chr6:88,964,624–88,964,798 | 1.0 kb | Proximal (<10kb) | 49 | |
| chr6:88,972,890–88,973,787 | 9.6 kb | Proximal (<10kb) Multiome | 345 | |
| chr6:89,079,845–89,082,207 | 116.9 kb | Distal (>10kb) Multiome | 1155 | |
| chr6:89,117,325–89,118,595 | 154.4 kb | Distal (>10kb) Multiome | 482 | |
| chr6:89,145,740–89,146,828 | 182.6 kb | Distal (>10kb) Multiome | 853 | |
| chr6:89,242,677–89,243,345 | 279.4 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the RNGTT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.