The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:176,361,095–176,362,133 | 176.1 kb | Distal (>10kb) Multiome | 877 | |
| chr5:176,365,184–176,366,532 | 172.4 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,388,019–176,389,614 | 148.9 kb | Distal (>10kb) Multiome | 1052 | |
| chr5:176,415,859–176,416,971 | 121.3 kb | Distal (>10kb) Multiome HiCAR | 827 | |
| chr5:176,441,967–176,442,454 | 95.7 kb | Distal (>10kb) Multiome | 166 | |
| chr5:176,447,162–176,449,016 | 89.6 kb | Distal (>10kb) Multiome | 859 | |
| chr5:176,536,385–176,538,671 | 100 bp | At TSS Multiome | 1006 | |
| chr5:176,541,333–176,544,229 | 3.8 kb | Proximal (<10kb) Multiome | 733 | |
| chr5:176,596,638–176,597,570 | 59.2 kb | Distal (>10kb) Multiome | 234 | |
| chr5:176,609,466–176,610,727 | 72.2 kb | Distal (>10kb) Multiome | 544 | |
| chr5:176,618,956–176,619,934 | 81.5 kb | Distal (>10kb) Multiome | 328 | |
| chr5:176,630,050–176,630,816 | 92.6 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,646,726–176,648,437 | 109.5 kb | Distal (>10kb) Multiome | 701 | |
| chr5:176,660,849–176,661,318 | 123.1 kb | Distal (>10kb) Multiome | 382 | |
| chr5:176,809,543–176,810,815 | 272.5 kb | Distal (>10kb) Multiome | 404 | |
| chr5:176,817,316–176,818,386 | 280.1 kb | Distal (>10kb) Multiome | 358 |
Genomic view of the RNF44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.