The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for RNF34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,209,800–121,210,863 | 190.0 kb | Distal (>10kb) Multiome | 894 | |
| chr12:121,230,137–121,230,781 | 169.6 kb | Distal (>10kb) Multiome | 326 | |
| chr12:121,280,329–121,281,482 | 119.3 kb | Distal (>10kb) Multiome | 112 | |
| chr12:121,295,441–121,297,879 | 103.2 kb | Distal (>10kb) Multiome | 801 | |
| chr12:121,351,979–121,352,906 | 47.6 kb | Distal (>10kb) Multiome | 928 | |
| chr12:121,399,561–121,400,983 | 106 bp | At TSS Multiome | 923 | |
| chr12:121,443,293–121,443,776 | 43.3 kb | Distal (>10kb) Multiome | 302 | |
| chr12:121,466,702–121,468,225 | 67.3 kb | Distal (>10kb) Multiome | 643 | |
| chr12:121,536,039–121,536,480 | 136.2 kb | Distal (>10kb) Multiome | 262 | |
| chr12:121,576,794–121,577,632 | 177.0 kb | Distal (>10kb) Multiome | 171 | |
| chr12:121,580,160–121,581,909 | 180.3 kb | Distal (>10kb) Multiome | 629 | |
| chr12:121,582,525–121,583,038 | 182.7 kb | Distal (>10kb) Multiome | 309 | |
| chr12:121,625,878–121,627,559 | 226.4 kb | Distal (>10kb) Multiome | 904 | |
| chr12:121,671,731–121,673,334 | 272.4 kb | Distal (>10kb) Multiome | 548 | |
| chr12:121,686,676–121,687,782 | 287.0 kb | Distal (>10kb) Multiome | 907 |
Genomic view of the RNF34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.