RNF26

ring finger protein 26 | MGC2642

The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]

Member of: DE-11

Biological processes 17 terms

endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endosome organization (GO:0007032)negative regulation of defense response to virus (GO:0050687)protein K11-linked ubiquitination (GO:0070979)protein binding (GO:0005515)protein localization to perinuclear region of cytoplasm (GO:1905719)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)regulation of type I interferon production (GO:0032479)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating RNF26 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RNF26

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr11:119,056,436–119,057,778	277.2 kb	Distal (>10kb) Multiome	815
chr11:119,067,446–119,068,100	266.8 kb	Distal (>10kb) Multiome	762
chr11:119,084,563–119,085,756	249.5 kb	Distal (>10kb) Multiome	846
chr11:119,093,969–119,096,070	239.0 kb	Distal (>10kb) Multiome	1046
chr11:119,101,351–119,102,791	232.4 kb	Distal (>10kb) Multiome HiCAR	871
chr11:119,106,906–119,107,993	227.2 kb	Distal (>10kb) Multiome HiCAR	650
chr11:119,120,857–119,122,037	213.1 kb	Distal (>10kb) Multiome	787
chr11:119,144,795–119,145,355	189.4 kb	Distal (>10kb) Multiome	230
chr11:119,148,816–119,149,933	184.9 kb	Distal (>10kb) Multiome	262
chr11:119,168,601–119,169,645	165.6 kb	Distal (>10kb) Multiome	794
chr11:119,205,241–119,207,150	128.4 kb	Distal (>10kb) Multiome	695
chr11:119,315,017–119,315,819	19.2 kb	Distal (>10kb) Multiome	270
chr11:119,316,693–119,317,760	17.3 kb	Distal (>10kb) Multiome	463
chr11:119,320,617–119,321,906	12.8 kb	Distal (>10kb) Multiome	516
chr11:119,334,140–119,334,815	124 bp	At TSS Multiome	577
chr11:119,337,716–119,338,797	3.8 kb	Proximal (<10kb) Multiome	412
chr11:119,339,587–119,340,902	5.6 kb	Proximal (<10kb) Multiome	477
chr11:119,356,332–119,357,013	22.2 kb	Distal (>10kb) Multiome	366
chr11:119,361,041–119,361,699	26.8 kb	Distal (>10kb) Multiome	431
chr11:119,363,939–119,364,561	29.7 kb	Distal (>10kb) Multiome	255
chr11:119,377,954–119,379,307	44.0 kb	Distal (>10kb) Multiome	307
chr11:119,380,894–119,382,060	47.2 kb	Distal (>10kb) Multiome	800
chr11:119,422,349–119,423,771	88.7 kb	Distal (>10kb) Multiome	235
chr11:119,481,243–119,481,846	147.1 kb	Distal (>10kb) Multiome	592
chr11:119,584,125–119,585,601	249.9 kb	Distal (>10kb) Multiome	491
chr11:119,616,862–119,617,652	282.6 kb	Distal (>10kb) Multiome	70

Genome Browser

Genomic view of the RNF26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.