Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF224. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF224 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF224, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:137,217,284–137,217,697 | 9.8 kb | Proximal (<10kb) | 456 | |
| chr9:137,218,870–137,219,281 | 8.2 kb | Proximal (<10kb) | 500 | |
| chr9:137,220,666–137,221,008 | 6.5 kb | Proximal (<10kb) | 99 | |
| chr9:137,221,373–137,224,294 | 3.2 kb | Proximal (<10kb) | 843 | |
| chr9:137,227,249–137,228,051 | at TSS | At TSS | 533 | |
| chr9:137,236,161–137,237,143 | 8.7 kb | Proximal (<10kb) | 748 |
Genomic view of the RNF224 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.