This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for RNF217. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF217 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF217, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:124,955,086–124,955,732 | 6.7 kb | Proximal (<10kb) | 96 | |
| chr6:124,961,736–124,963,798 | 292 bp | At TSS Multiome | 660 | |
| chr6:125,099,255–125,100,053 | 137.3 kb | Distal (>10kb) Multiome | 540 | |
| chr6:125,153,568–125,155,310 | 192.5 kb | Distal (>10kb) Multiome HiCAR | 927 | |
| chr6:125,952,889–125,953,903 | 991.0 kb | Distal (>10kb) Multiome HiCAR | 343 | |
| chr6:125,956,540–125,957,527 | 994.4 kb | Distal (>10kb) Multiome HiCAR | 1085 |
Genomic view of the RNF217 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.