Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF208. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF208 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF208, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,943,250–136,945,621 | 277.6 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 272.1 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 243.7 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 229.9 kb | Distal (>10kb) Multiome | 720 | |
| chr9:137,027,536–137,029,054 | 194.0 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,029,231–137,029,652 | 192.7 kb | Distal (>10kb) Multiome | 386 | |
| chr9:137,045,334–137,046,838 | 175.7 kb | Distal (>10kb) Multiome | 829 | |
| chr9:137,053,352–137,054,892 | 168.1 kb | Distal (>10kb) Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 154.1 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr9:137,069,879–137,071,138 | 151.6 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 144.8 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 135.4 kb | Distal (>10kb) Multiome | 890 | |
| chr9:137,129,244–137,130,499 | 92.4 kb | Distal (>10kb) Multiome HiCAR | 823 | |
| chr9:137,167,984–137,170,155 | 52.8 kb | Distal (>10kb) Multiome HiCAR | 560 | |
| chr9:137,188,099–137,189,538 | 33.5 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr9:137,200,175–137,201,689 | 21.4 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr9:137,205,371–137,205,975 | 16.6 kb | Distal (>10kb) Multiome HiCAR | 758 | |
| chr9:137,217,284–137,217,697 | 4.5 kb | Proximal (<10kb) | 456 | |
| chr9:137,218,870–137,219,281 | 3.0 kb | Proximal (<10kb) | 500 | |
| chr9:137,220,666–137,221,008 | 1.2 kb | Proximal (<10kb) | 99 | |
| chr9:137,221,373–137,224,294 | 307 bp | At TSS Multiome | 843 | |
| chr9:137,227,249–137,228,051 | 5.4 kb | Proximal (<10kb) Multiome | 533 | |
| chr9:137,236,161–137,237,143 | 14.4 kb | Distal (>10kb) Multiome HiCAR | 748 | |
| chr9:137,239,991–137,242,933 | 18.8 kb | Distal (>10kb) Multiome | 1117 | |
| chr9:137,243,659–137,245,307 | 22.1 kb | Distal (>10kb) Multiome | 471 | |
| chr9:137,253,801–137,256,036 | 33.1 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 58.9 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,859–137,296,916 | 73.3 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 80.2 kb | Distal (>10kb) Multiome | 790 | |
| chr9:137,316,104–137,316,916 | 94.1 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 184.9 kb | Distal (>10kb) Multiome | 427 | |
| chr9:137,422,664–137,424,024 | 201.0 kb | Distal (>10kb) Multiome | 896 | |
| chr9:137,441,270–137,441,970 | 219.3 kb | Distal (>10kb) Multiome | 568 | |
| chr9:137,453,153–137,455,543 | 231.8 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 237.1 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 239.6 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the RNF208 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.