This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for RNF19B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF19B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF19B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:32,712,054–32,712,688 | 252.4 kb | Distal (>10kb) Multiome | 645 | |
| chr1:32,715,926–32,717,303 | 248.0 kb | Distal (>10kb) Multiome | 551 | |
| chr1:32,736,558–32,737,765 | 227.8 kb | Distal (>10kb) Multiome | 507 | |
| chr1:32,753,606–32,755,507 | 210.8 kb | Distal (>10kb) Multiome | 565 | |
| chr1:32,758,502–32,759,280 | 205.9 kb | Distal (>10kb) Multiome | 144 | |
| chr1:32,765,137–32,765,925 | 199.1 kb | Distal (>10kb) Multiome | 122 | |
| chr1:32,772,938–32,773,451 | 191.7 kb | Distal (>10kb) Multiome | 441 | |
| chr1:32,816,876–32,818,654 | 147.3 kb | Distal (>10kb) Multiome | 1138 | |
| chr1:32,870,570–32,871,148 | 94.0 kb | Distal (>10kb) Multiome | 182 | |
| chr1:32,886,388–32,887,030 | 78.1 kb | Distal (>10kb) Multiome | 917 | |
| chr1:32,892,705–32,893,946 | 71.7 kb | Distal (>10kb) Multiome | 444 | |
| chr1:32,901,143–32,901,775 | 63.3 kb | Distal (>10kb) Multiome | 393 | |
| chr1:32,963,782–32,965,243 | 95 bp | At TSS Multiome | 882 | |
| chr1:32,972,824–32,973,439 | 8.3 kb | Proximal (<10kb) Multiome | 489 | |
| chr1:33,036,391–33,037,199 | 72.2 kb | Distal (>10kb) Multiome | 948 | |
| chr1:33,080,764–33,081,783 | 116.3 kb | Distal (>10kb) Multiome | 556 | |
| chr1:33,127,180–33,127,648 | 162.6 kb | Distal (>10kb) Multiome | 877 | |
| chr1:33,152,752–33,153,392 | 188.3 kb | Distal (>10kb) Multiome | 151 | |
| chr1:33,180,551–33,182,306 | 216.1 kb | Distal (>10kb) Multiome | 692 | |
| chr1:33,255,428–33,256,795 | 290.9 kb | Distal (>10kb) Multiome | 509 |
Genomic view of the RNF19B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.