Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF182. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF182 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF182, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:13,710,505–13,712,451 | 213.0 kb | Distal (>10kb) Multiome | 996 | |
| chr6:13,813,584–13,814,884 | 110.5 kb | Distal (>10kb) Multiome | 1028 | |
| chr6:13,859,849–13,861,074 | 64.5 kb | Distal (>10kb) Multiome | 81 | |
| chr6:13,873,408–13,874,382 | 51.1 kb | Distal (>10kb) Multiome | 915 | |
| chr6:13,923,928–13,925,299 | 102 bp | At TSS Multiome | 566 | |
| chr6:14,117,134–14,118,295 | 192.7 kb | Distal (>10kb) Multiome | 640 | |
| chr6:14,210,686–14,212,342 | 286.3 kb | Distal (>10kb) Multiome | 895 | |
| chr6:15,409,286–15,410,423 | 1484.8 kb | Distal (>10kb) Multiome HiCAR | 247 | |
| chr6:15,460,916–15,461,553 | 1536.3 kb | Distal (>10kb) Multiome HiCAR | 161 |
Genomic view of the RNF182 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.