RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
Transcription factors with Perturb-seq knockdown data for RNF181. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF181 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF181, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:85,327,503–85,328,538 | 267.7 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:85,354,014–85,355,224 | 241.1 kb | Distal (>10kb) Multiome | 962 | |
| chr2:85,413,587–85,414,333 | 181.9 kb | Distal (>10kb) Multiome | 351 | |
| chr2:85,418,133–85,419,210 | 177.1 kb | Distal (>10kb) Multiome | 885 | |
| chr2:85,420,473–85,421,406 | 174.9 kb | Distal (>10kb) Multiome HiCAR | 853 | |
| chr2:85,437,445–85,438,463 | 157.9 kb | Distal (>10kb) Multiome | 501 | |
| chr2:85,455,501–85,456,436 | 139.8 kb | Distal (>10kb) Multiome | 268 | |
| chr2:85,468,626–85,469,195 | 126.9 kb | Distal (>10kb) Multiome | 496 | |
| chr2:85,537,623–85,540,152 | 58.0 kb | Distal (>10kb) Multiome | 1210 | |
| chr2:85,546,252–85,547,149 | 49.2 kb | Distal (>10kb) Multiome | 418 | |
| chr2:85,561,042–85,561,982 | 34.2 kb | Distal (>10kb) Multiome | 903 | |
| chr2:85,577,411–85,578,045 | 18.2 kb | Distal (>10kb) Multiome | 505 | |
| chr2:85,578,935–85,580,041 | 16.1 kb | Distal (>10kb) Multiome | 275 | |
| chr2:85,584,249–85,584,853 | 11.1 kb | Distal (>10kb) Multiome | 633 | |
| chr2:85,595,068–85,596,226 | 86 bp | At TSS Multiome | 804 | |
| chr2:85,601,954–85,603,493 | 7.0 kb | Proximal (<10kb) Multiome | 852 | |
| chr2:85,611,558–85,612,589 | 16.3 kb | Distal (>10kb) Multiome | 875 | |
| chr2:85,615,831–85,616,609 | 20.5 kb | Distal (>10kb) Multiome | 898 | |
| chr2:85,678,904–85,679,599 | 83.6 kb | Distal (>10kb) Multiome | 445 | |
| chr2:85,753,145–85,755,032 | 158.1 kb | Distal (>10kb) Multiome | 527 | |
| chr2:85,827,451–85,827,914 | 231.9 kb | Distal (>10kb) Multiome | 364 | |
| chr2:85,888,294–85,889,666 | 293.3 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the RNF181 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.