Enables K63-linked polyubiquitin modification-dependent protein binding activity; nucleosome binding activity; and ubiquitin-modified histone reader activity. Involved in double-strand break repair via homologous recombination and negative regulation of double-strand break repair. Located in cytosol; nuclear lumen; and site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF169. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF169 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF169, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:74,467,393–74,467,865 | 281.4 kb | Distal (>10kb) Multiome | 174 | |
| chr11:74,492,667–74,494,411 | 255.4 kb | Distal (>10kb) Multiome | 897 | |
| chr11:74,592,212–74,593,000 | 156.3 kb | Distal (>10kb) Multiome | 716 | |
| chr11:74,731,155–74,731,658 | 17.4 kb | Distal (>10kb) Multiome | 131 | |
| chr11:74,748,226–74,749,731 | 17 bp | At TSS Multiome | 854 | |
| chr11:74,948,631–74,949,595 | 200.3 kb | Distal (>10kb) Multiome | 870 | |
| chr11:74,988,546–74,989,331 | 240.0 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the RNF169 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.