Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process; positive regulation of dendrite extension; and protein ubiquitination. Predicted to be located in cell body. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF157. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF157 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF157, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,940,734–75,941,471 | 299.4 kb | Distal (>10kb) Multiome | 982 | |
| chr17:75,978,646–75,980,102 | 261.1 kb | Distal (>10kb) Multiome | 1090 | |
| chr17:75,983,292–75,984,226 | 256.6 kb | Distal (>10kb) Multiome | 236 | |
| chr17:76,014,120–76,014,727 | 226.1 kb | Distal (>10kb) Multiome | 489 | |
| chr17:76,029,331–76,030,158 | 210.8 kb | Distal (>10kb) Multiome | 722 | |
| chr17:76,072,173–76,072,853 | 167.9 kb | Distal (>10kb) Multiome | 893 | |
| chr17:76,074,414–76,075,796 | 165.8 kb | Distal (>10kb) Multiome | 280 | |
| chr17:76,103,272–76,104,343 | 136.7 kb | Distal (>10kb) Multiome | 798 | |
| chr17:76,121,142–76,122,265 | 119.0 kb | Distal (>10kb) Multiome | 689 | |
| chr17:76,132,004–76,133,216 | 107.7 kb | Distal (>10kb) Multiome | 536 | |
| chr17:76,135,151–76,135,652 | 105.2 kb | Distal (>10kb) Multiome | 104 | |
| chr17:76,141,012–76,141,958 | 99.1 kb | Distal (>10kb) Multiome | 616 | |
| chr17:76,240,278–76,241,169 | 259 bp | At TSS Multiome | 560 | |
| chr17:76,264,834–76,266,286 | 24.6 kb | Distal (>10kb) Multiome | 868 | |
| chr17:76,353,245–76,354,535 | 113.5 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:76,383,686–76,385,081 | 144.1 kb | Distal (>10kb) Multiome | 823 | |
| chr17:76,385,493–76,386,382 | 145.6 kb | Distal (>10kb) Multiome | 935 | |
| chr17:76,452,469–76,453,735 | 212.8 kb | Distal (>10kb) Multiome | 726 | |
| chr17:76,500,907–76,502,333 | 261.0 kb | Distal (>10kb) Multiome | 728 | |
| chr17:76,506,248–76,506,840 | 266.0 kb | Distal (>10kb) Multiome | 550 | |
| chr17:76,537,326–76,538,627 | 297.2 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the RNF157 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.