Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF146. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF146 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF146, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:127,118,017–127,121,704 | 148.3 kb | Distal (>10kb) Multiome | 622 | |
| chr6:127,266,246–127,267,883 | 46 bp | At TSS Multiome | 1001 | |
| chr6:127,297,458–127,298,045 | 30.9 kb | Distal (>10kb) Multiome | 248 | |
| chr6:127,342,123–127,344,593 | 76.5 kb | Distal (>10kb) Multiome | 975 | |
| chr6:127,483,397–127,484,154 | 216.8 kb | Distal (>10kb) Multiome | 288 | |
| chr6:127,514,397–127,517,019 | 249.6 kb | Distal (>10kb) Multiome | 855 | |
| chr6:127,518,139–127,519,697 | 252.2 kb | Distal (>10kb) Multiome | 431 |
Genomic view of the RNF146 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.