The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF126. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF126 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF126, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:408,569–409,459 | 254.1 kb | Distal (>10kb) Multiome | 310 | |
| chr19:459,789–461,382 | 203.0 kb | Distal (>10kb) Multiome | 545 | |
| chr19:461,557–462,453 | 201.2 kb | Distal (>10kb) Multiome | 580 | |
| chr19:488,399–489,918 | 174.1 kb | Distal (>10kb) Multiome | 898 | |
| chr19:506,451–508,366 | 156.0 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:510,509–511,797 | 152.3 kb | Distal (>10kb) Multiome | 739 | |
| chr19:518,865–519,356 | 144.1 kb | Distal (>10kb) Multiome | 151 | |
| chr19:530,809–533,397 | 131.8 kb | Distal (>10kb) Multiome | 856 | |
| chr19:572,071–573,594 | 90.7 kb | Distal (>10kb) Multiome | 888 | |
| chr19:588,127–589,976 | 74.9 kb | Distal (>10kb) Multiome | 526 | |
| chr19:632,653–633,806 | 29.6 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 23.4 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 131 bp | At TSS Multiome | 723 | |
| chr19:664,940–665,345 | 1.7 kb | Proximal (<10kb) | 562 | |
| chr19:679,616–681,731 | 17.5 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 40.8 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 45.6 kb | Distal (>10kb) Multiome | 317 | |
| chr19:796,668–798,362 | 134.0 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 158.9 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 199.0 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 230.0 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 254.6 kb | Distal (>10kb) Multiome | 711 | |
| chr19:924,743–926,242 | 262.5 kb | Distal (>10kb) Multiome | 796 | |
| chr19:927,058–927,629 | 264.2 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the RNF126 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.