The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for RNF123. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF123 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF123, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,020,066–49,022,597 | 667.8 kb | Distal (>10kb) Multiome HiCAR | 1064 | |
| chr3:49,028,856–49,029,800 | 660.1 kb | Distal (>10kb) Multiome HiCAR | 974 | |
| chr3:49,411,409–49,412,844 | 277.4 kb | Distal (>10kb) Multiome | 899 | |
| chr3:49,422,179–49,422,905 | 267.0 kb | Distal (>10kb) Multiome | 453 | |
| chr3:49,428,857–49,429,869 | 260.1 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,461,484–49,462,134 | 227.8 kb | Distal (>10kb) Multiome | 207 | |
| chr3:49,468,926–49,470,930 | 219.3 kb | Distal (>10kb) Multiome | 919 | |
| chr3:49,539,369–49,540,584 | 149.6 kb | Distal (>10kb) Multiome HiCAR | 628 | |
| chr3:49,553,618–49,555,244 | 135.1 kb | Distal (>10kb) Multiome | 710 | |
| chr3:49,718,116–49,720,106 | 30.1 kb | Distal (>10kb) Multiome | 450 | |
| chr3:49,723,361–49,724,517 | 34.5 kb | Distal (>10kb) Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 97.1 kb | Distal (>10kb) Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 113.3 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 167.1 kb | Distal (>10kb) Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 180.4 kb | Distal (>10kb) Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 214.4 kb | Distal (>10kb) Multiome | 415 | |
| chr3:49,929,290–49,930,212 | 240.2 kb | Distal (>10kb) Multiome | 799 | |
| chr3:49,939,635–49,940,747 | 250.5 kb | Distal (>10kb) Multiome | 949 |
Genomic view of the RNF123 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.