The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:50,959,563–50,960,794 | 276.0 kb | Distal (>10kb) Multiome | 976 | |
| chr1:50,968,048–50,970,309 | 267.8 kb | Distal (>10kb) Multiome | 1030 | |
| chr1:50,977,595–50,978,655 | 258.1 kb | Distal (>10kb) Multiome | 755 | |
| chr1:51,234,986–51,237,165 | 28 bp | At TSS Multiome | 868 | |
| chr1:51,296,022–51,297,319 | 60.7 kb | Distal (>10kb) Multiome | 580 | |
| chr1:51,330,127–51,331,039 | 94.3 kb | Distal (>10kb) Multiome | 288 | |
| chr1:51,344,517–51,345,671 | 108.8 kb | Distal (>10kb) Multiome | 345 | |
| chr1:51,517,972–51,519,630 | 281.8 kb | Distal (>10kb) Multiome | 979 |
Genomic view of the RNF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.