RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for RNASEH2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASEH2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASEH2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:49,791,339–49,793,749 | 1116.9 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr13:49,847,783–49,848,275 | 1061.7 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr13:49,935,563–49,937,380 | 973.3 kb | Distal (>10kb) Multiome HiCAR | 924 | |
| chr13:49,995,900–49,997,790 | 912.7 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr13:50,080,906–50,083,082 | 827.6 kb | Distal (>10kb) Multiome HiCAR | 885 | |
| chr13:50,123,622–50,126,557 | 785.3 kb | Distal (>10kb) Multiome HiCAR | 1075 | |
| chr13:50,129,633–50,130,893 | 779.6 kb | Distal (>10kb) Multiome HiCAR | 289 | |
| chr13:50,676,407–50,677,028 | 233.0 kb | Distal (>10kb) Multiome | 203 | |
| chr13:50,779,449–50,780,341 | 129.9 kb | Distal (>10kb) Multiome | 141 | |
| chr13:50,842,911–50,844,242 | 66.1 kb | Distal (>10kb) Multiome | 210 | |
| chr13:50,909,544–50,910,786 | 122 bp | At TSS Multiome | 827 | |
| chr13:50,912,020–50,912,346 | 2.3 kb | Proximal (<10kb) | 356 | |
| chr13:51,101,590–51,102,215 | 192.0 kb | Distal (>10kb) Multiome | 123 | |
| chr13:51,122,652–51,123,430 | 213.3 kb | Distal (>10kb) Multiome | 298 | |
| chr13:51,125,567–51,126,048 | 216.0 kb | Distal (>10kb) Multiome | 224 | |
| chr13:51,146,222–51,147,378 | 237.0 kb | Distal (>10kb) Multiome | 79 | |
| chr13:51,147,892–51,149,246 | 238.7 kb | Distal (>10kb) Multiome | 319 | |
| chr13:51,169,207–51,170,289 | 260.1 kb | Distal (>10kb) Multiome | 174 |
Genomic view of the RNASEH2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.