Transcription factors with Perturb-seq knockdown data for RN7SL573P. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RN7SL573P upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RN7SL573P, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:75,033,550–75,035,757 | 6.0 kb | Proximal (<10kb) | 1228 | |
| chr17:75,036,552–75,037,040 | 4.7 kb | Proximal (<10kb) | 387 | |
| chr17:75,041,736–75,042,280 | at TSS | At TSS | 108 | |
| chr17:75,044,818–75,045,656 | 3.1 kb | Proximal (<10kb) | 154 | |
| chr17:75,046,451–75,047,855 | 4.7 kb | Proximal (<10kb) | 961 |
Genomic view of the RN7SL573P locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.