The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL2, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).[supplied by OMIM, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RN7SL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RN7SL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RN7SL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,852,270–49,853,410 | 9.4 kb | Proximal (<10kb) | 813 | |
| chr14:49,853,662–49,854,089 | 8.8 kb | Proximal (<10kb) | 439 | |
| chr14:49,861,592–49,863,464 | at TSS | At TSS | 1038 | |
| chr14:49,865,469–49,865,638 | 2.6 kb | Proximal (<10kb) | 204 | |
| chr14:49,867,745–49,868,682 | 4.9 kb | Proximal (<10kb) | 699 |
Genomic view of the RN7SL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.