Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RMND5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMND5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMND5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:178,075,958–178,076,432 | 54.8 kb | Distal (>10kb) Multiome HiCAR | 336 | |
| chr5:178,113,136–178,114,807 | 17.5 kb | Distal (>10kb) Multiome | 620 | |
| chr5:178,120,968–178,121,162 | 9.8 kb | Proximal (<10kb) | 483 | |
| chr5:178,126,550–178,126,926 | 4.1 kb | Proximal (<10kb) | 187 | |
| chr5:178,130,402–178,131,452 | 96 bp | At TSS Multiome | 875 | |
| chr5:178,153,562–178,154,391 | 23.0 kb | Distal (>10kb) Multiome | 695 | |
| chr5:178,164,084–178,164,721 | 33.4 kb | Distal (>10kb) Multiome | 514 | |
| chr5:178,179,895–178,180,860 | 49.4 kb | Distal (>10kb) Multiome | 283 | |
| chr5:178,203,935–178,205,708 | 73.4 kb | Distal (>10kb) Multiome | 995 | |
| chr5:178,231,971–178,233,141 | 101.6 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the RMND5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.