Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RMND5A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMND5A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMND5A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:86,440,468–86,442,936 | 279.2 kb | Distal (>10kb) Multiome | 1229 | |
| chr2:86,562,703–86,563,941 | 157.0 kb | Distal (>10kb) Multiome | 1017 | |
| chr2:86,622,458–86,624,092 | 96.5 kb | Distal (>10kb) Multiome | 913 | |
| chr2:86,719,886–86,720,543 | 85 bp | At TSS Multiome | 245 | |
| chr2:86,785,940–86,786,595 | 66.0 kb | Distal (>10kb) Multiome | 161 | |
| chr2:86,807,228–86,809,045 | 87.5 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the RMND5A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.