The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Transcription factors with Perturb-seq knockdown data for RLIM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RLIM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RLIM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:74,325,234–74,326,322 | 288.9 kb | Distal (>10kb) Multiome | 229 | |
| chrX:74,419,854–74,421,997 | 194.1 kb | Distal (>10kb) Multiome | 370 | |
| chrX:74,422,455–74,423,310 | 191.6 kb | Distal (>10kb) Multiome | 202 | |
| chrX:74,535,197–74,537,347 | 78.0 kb | Distal (>10kb) Multiome | 425 | |
| chrX:74,614,086–74,615,093 | 26 bp | At TSS Multiome | 611 | |
| chrX:76,127,009–76,127,787 | 1512.9 kb | Distal (>10kb) Multiome HiCAR | 59 |
Genomic view of the RLIM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.