This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RIPK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIPK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIPK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:89,735,590–89,737,765 | 21.7 kb | Distal (>10kb) Multiome | 299 | |
| chr8:89,755,844–89,756,405 | 1.4 kb | Proximal (<10kb) | 60 | |
| chr8:89,757,049–89,758,721 | 116 bp | At TSS Multiome | 975 | |
| chr8:89,759,218–89,759,591 | 1.4 kb | Proximal (<10kb) | 223 | |
| chr8:89,901,706–89,903,339 | 144.6 kb | Distal (>10kb) Multiome | 906 | |
| chr8:89,983,654–89,985,025 | 226.6 kb | Distal (>10kb) Multiome | 1128 | |
| chr8:89,992,539–89,993,861 | 235.1 kb | Distal (>10kb) Multiome | 132 | |
| chr8:90,000,653–90,002,462 | 243.5 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the RIPK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.