Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIOK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIOK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIOK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:96,934,346–96,937,145 | 248.2 kb | Distal (>10kb) Multiome | 1171 | |
| chr5:97,142,252–97,143,299 | 40.5 kb | Distal (>10kb) Multiome | 308 | |
| chr5:97,182,741–97,184,087 | 322 bp | At TSS Multiome | 963 | |
| chr5:97,192,555–97,193,805 | 9.9 kb | Proximal (<10kb) Multiome | 303 | |
| chr5:97,400,449–97,401,105 | 217.5 kb | Distal (>10kb) Multiome | 185 | |
| chr5:98,767,947–98,770,957 | 1586.2 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr5:98,772,851–98,774,947 | 1590.2 kb | Distal (>10kb) Multiome HiCAR | 1033 |
Genomic view of the RIOK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.