Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endocytosis. Predicted to be located in ruffle. Predicted to be active in cytosol and endocytic vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RINL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RINL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RINL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,595,857–38,597,322 | 273.6 kb | Distal (>10kb) Multiome | 478 | |
| chr19:38,617,752–38,619,569 | 251.1 kb | Distal (>10kb) Multiome | 835 | |
| chr19:38,647,137–38,648,653 | 222.5 kb | Distal (>10kb) Multiome | 856 | |
| chr19:38,666,103–38,666,668 | 203.8 kb | Distal (>10kb) Multiome | 317 | |
| chr19:38,683,677–38,684,144 | 186.4 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,734,491–38,735,702 | 134.7 kb | Distal (>10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 133.0 kb | Distal (>10kb) Multiome | 493 | |
| chr19:38,831,191–38,832,119 | 38.2 kb | Distal (>10kb) Multiome | 931 | |
| chr19:38,849,166–38,852,789 | 19.7 kb | Distal (>10kb) Multiome | 1139 | |
| chr19:38,869,729–38,870,536 | 43 bp | At TSS Multiome | 350 | |
| chr19:38,899,267–38,900,530 | 29.8 kb | Distal (>10kb) Multiome | 886 | |
| chr19:38,930,044–38,931,363 | 60.7 kb | Distal (>10kb) Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 79.9 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 105.6 kb | Distal (>10kb) Multiome | 846 | |
| chr19:39,030,958–39,033,042 | 161.6 kb | Distal (>10kb) Multiome | 763 | |
| chr19:39,125,485–39,126,290 | 255.7 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the RINL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.