Predicted to enable transmembrane transporter binding activity. Predicted to be involved in regulation of membrane potential; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in synaptic membrane. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIMS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIMS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIMS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,521,574–44,522,457 | 288.5 kb | Distal (>10kb) Multiome | 937 | |
| chr20:44,531,682–44,532,180 | 278.7 kb | Distal (>10kb) Multiome | 880 | |
| chr20:44,609,775–44,610,281 | 200.4 kb | Distal (>10kb) Multiome | 727 | |
| chr20:44,642,246–44,643,140 | 167.8 kb | Distal (>10kb) Multiome | 469 | |
| chr20:44,651,099–44,652,334 | 158.8 kb | Distal (>10kb) Multiome | 641 | |
| chr20:44,745,652–44,746,316 | 64.6 kb | Distal (>10kb) Multiome | 321 | |
| chr20:44,810,403–44,810,885 | 22 bp | At TSS Multiome | 181 | |
| chr20:44,884,968–44,886,235 | 75.0 kb | Distal (>10kb) Multiome | 913 | |
| chr20:44,909,510–44,910,396 | 99.5 kb | Distal (>10kb) Multiome | 810 | |
| chr20:44,911,292–44,911,995 | 101.1 kb | Distal (>10kb) Multiome | 532 | |
| chr20:44,960,068–44,960,912 | 149.9 kb | Distal (>10kb) Multiome | 1025 | |
| chr20:44,966,035–44,967,090 | 155.9 kb | Distal (>10kb) Multiome | 1001 | |
| chr20:45,098,253–45,098,840 | 288.0 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the RIMS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.