Predicted to enable transmembrane transporter binding activity. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in several processes, including regulated exocytosis; regulation of synapse organization; and regulation of synaptic vesicle exocytosis. Predicted to be located in presynaptic active zone. Predicted to be active in several cellular components, including postsynaptic cytosol; presynaptic active zone cytoplasmic component; and presynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIMS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIMS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIMS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:40,373,298–40,374,444 | 292.0 kb | Distal (>10kb) Multiome | 747 | |
| chr1:40,449,758–40,450,645 | 215.5 kb | Distal (>10kb) Multiome | 807 | |
| chr1:40,476,972–40,477,791 | 188.3 kb | Distal (>10kb) Multiome | 683 | |
| chr1:40,508,401–40,509,160 | 156.9 kb | Distal (>10kb) Multiome | 805 | |
| chr1:40,531,425–40,532,089 | 134.1 kb | Distal (>10kb) Multiome | 724 | |
| chr1:40,665,223–40,666,079 | 6 bp | At TSS Multiome | 465 | |
| chr1:40,668,959–40,669,157 | 3.3 kb | Proximal (<10kb) | 335 | |
| chr1:40,691,236–40,692,758 | 26.1 kb | Distal (>10kb) Multiome | 1088 | |
| chr1:40,708,827–40,709,450 | 43.5 kb | Distal (>10kb) Multiome | 526 | |
| chr1:40,783,386–40,784,649 | 118.2 kb | Distal (>10kb) Multiome | 448 | |
| chr1:40,802,183–40,803,007 | 136.8 kb | Distal (>10kb) Multiome | 455 | |
| chr1:40,818,171–40,819,026 | 153.1 kb | Distal (>10kb) Multiome | 236 | |
| chr1:40,861,144–40,862,924 | 196.8 kb | Distal (>10kb) Multiome | 724 | |
| chr1:40,952,369–40,952,943 | 287.0 kb | Distal (>10kb) Multiome | 442 |
Genomic view of the RIMS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.