Predicted to enable voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in neuromuscular synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of presynaptic membrane potential. Predicted to be located in plasma membrane and synapse. Predicted to be active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIMBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIMBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIMBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:130,514,132–130,514,609 | 119.5 kb | Distal (>10kb) Multiome | 63 | |
| chr12:130,633,800–130,634,086 | at TSS | At TSS | 141 | |
| chr12:130,716,209–130,717,026 | 82.6 kb | Distal (>10kb) Multiome | 196 | |
| chr12:130,818,705–130,819,446 | 185.3 kb | Distal (>10kb) Multiome | 387 | |
| chr12:130,838,421–130,839,832 | 205.3 kb | Distal (>10kb) Multiome | 714 | |
| chr12:130,853,443–130,853,949 | 219.9 kb | Distal (>10kb) Multiome | 118 | |
| chr12:130,870,687–130,872,721 | 238.1 kb | Distal (>10kb) Multiome | 904 |
Genomic view of the RIMBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.