Predicted to enable G-protein alpha-subunit binding activity; GTPase regulator activity; and protein folding chaperone. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Predicted to be located in cell cortex and membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIC8A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIC8A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIC8A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:206,950–208,051 | 239 bp | At TSS Multiome | 884 | |
| chr11:208,471–209,205 | 1.1 kb | Proximal (<10kb) Multiome | 593 | |
| chr11:235,864–237,255 | 28.8 kb | Distal (>10kb) Multiome | 874 | |
| chr11:288,466–289,320 | 81.3 kb | Distal (>10kb) Multiome | 400 | |
| chr11:313,383–314,476 | 106.2 kb | Distal (>10kb) Multiome | 421 | |
| chr11:316,978–318,064 | 109.5 kb | Distal (>10kb) Multiome | 100 | |
| chr11:333,722–334,610 | 126.5 kb | Distal (>10kb) Multiome | 238 | |
| chr11:355,654–356,479 | 148.5 kb | Distal (>10kb) Multiome | 894 | |
| chr11:370,037–370,556 | 162.5 kb | Distal (>10kb) Multiome | 205 | |
| chr11:406,008–408,661 | 199.5 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 209.6 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 240.5 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 242.5 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 299.4 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the RIC8A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.