This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the folding and assembly of these receptor subunits in the endoplasmic reticulum and expression on the cell surface. This protein contains an N-terminal transmembrane domain, a proline-rich spacer, and a cytosolic C-terminal coiled-coil domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for RIC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:7,905,555–7,906,470 | 262.9 kb | Distal (>10kb) Multiome | 98 | |
| chr11:7,909,636–7,910,173 | 259.2 kb | Distal (>10kb) Multiome | 37 | |
| chr11:7,986,569–7,987,645 | 181.8 kb | Distal (>10kb) Multiome | 879 | |
| chr11:8,018,776–8,020,008 | 149.8 kb | Distal (>10kb) Multiome | 365 | |
| chr11:8,032,871–8,033,670 | 135.6 kb | Distal (>10kb) Multiome | 307 | |
| chr11:8,080,656–8,082,014 | 87.8 kb | Distal (>10kb) Multiome | 370 | |
| chr11:8,168,430–8,169,450 | 122 bp | At TSS Multiome | 329 | |
| chr11:8,178,170–8,178,721 | 9.1 kb | Proximal (<10kb) | 11 | |
| chr11:8,192,451–8,193,309 | 23.8 kb | Distal (>10kb) Multiome | 185 | |
| chr11:8,261,997–8,263,550 | 93.8 kb | Distal (>10kb) Multiome | 309 | |
| chr11:8,267,870–8,269,102 | 99.6 kb | Distal (>10kb) Multiome | 247 | |
| chr11:8,328,690–8,329,408 | 160.0 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the RIC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.