Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Located in cytosol and membrane. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:4,678,800–4,680,345 | 949.5 kb | Distal (>10kb) Multiome HiCAR | 960 | |
| chr9:4,740,523–4,742,116 | 887.8 kb | Distal (>10kb) Multiome HiCAR | 942 | |
| chr9:4,792,132–4,794,058 | 836.3 kb | Distal (>10kb) Multiome HiCAR | 871 | |
| chr9:5,437,323–5,438,772 | 191.2 kb | Distal (>10kb) Multiome | 858 | |
| chr9:5,450,352–5,451,061 | 178.5 kb | Distal (>10kb) Multiome | 726 | |
| chr9:5,484,921–5,486,234 | 143.5 kb | Distal (>10kb) Multiome | 123 | |
| chr9:5,628,133–5,629,918 | 202 bp | At TSS Multiome | 812 | |
| chr9:5,630,019–5,630,347 | 913 bp | At TSS | 181 | |
| chr9:5,831,978–5,833,476 | 203.9 kb | Distal (>10kb) Multiome | 896 | |
| chr9:5,885,989–5,886,773 | 257.2 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the RIC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.