Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within several processes, including focal adhesion assembly; glomerular filtration; and renal albumin absorption. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHPN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHPN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHPN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,266,869–143,267,949 | 101.5 kb | Distal (>10kb) Multiome | 733 | |
| chr8:143,290,813–143,291,709 | 77.5 kb | Distal (>10kb) Multiome | 909 | |
| chr8:143,334,216–143,335,267 | 34.0 kb | Distal (>10kb) Multiome | 688 | |
| chr8:143,368,147–143,369,893 | 133 bp | At TSS Multiome | 698 | |
| chr8:143,407,212–143,408,612 | 39.2 kb | Distal (>10kb) Multiome | 447 | |
| chr8:143,428,968–143,431,754 | 62.0 kb | Distal (>10kb) Multiome | 743 | |
| chr8:143,540,714–143,542,061 | 172.6 kb | Distal (>10kb) Multiome | 849 | |
| chr8:143,553,122–143,554,177 | 184.8 kb | Distal (>10kb) Multiome | 775 | |
| chr8:143,558,225–143,558,936 | 189.6 kb | Distal (>10kb) Multiome | 600 | |
| chr8:143,567,166–143,570,227 | 200.3 kb | Distal (>10kb) Multiome | 485 | |
| chr8:143,571,367–143,572,283 | 202.9 kb | Distal (>10kb) Multiome | 443 | |
| chr8:143,577,641–143,578,799 | 209.5 kb | Distal (>10kb) Multiome | 470 | |
| chr8:143,596,744–143,599,643 | 228.7 kb | Distal (>10kb) Multiome | 973 | |
| chr8:143,608,979–143,610,357 | 240.9 kb | Distal (>10kb) Multiome | 735 | |
| chr8:143,617,068–143,618,380 | 248.8 kb | Distal (>10kb) Multiome | 823 | |
| chr8:143,635,715–143,636,601 | 267.1 kb | Distal (>10kb) Multiome | 786 |
Genomic view of the RHPN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.