Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to ionizing radiation; and regulation of cell migration. Located in cleavage furrow and endosome membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHOB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:20,207,998–20,208,855 | 238.7 kb | Distal (>10kb) Multiome | 346 | |
| chr2:20,223,290–20,226,136 | 223.4 kb | Distal (>10kb) Multiome | 1023 | |
| chr2:20,242,059–20,243,494 | 204.6 kb | Distal (>10kb) Multiome | 372 | |
| chr2:20,350,092–20,352,594 | 96.2 kb | Distal (>10kb) Multiome | 1127 | |
| chr2:20,443,380–20,443,902 | 3.2 kb | Proximal (<10kb) | 260 | |
| chr2:20,445,280–20,445,662 | 1.4 kb | Proximal (<10kb) | 77 | |
| chr2:20,446,303–20,448,812 | 87 bp | At TSS Multiome | 1072 | |
| chr2:20,450,052–20,450,935 | 3.0 kb | Proximal (<10kb) | 591 | |
| chr2:20,451,812–20,452,773 | 4.7 kb | Proximal (<10kb) | 223 | |
| chr2:20,524,538–20,525,515 | 77.8 kb | Distal (>10kb) Multiome | 598 | |
| chr2:20,635,654–20,636,525 | 188.9 kb | Distal (>10kb) Multiome HiCAR | 590 | |
| chr2:20,642,270–20,642,905 | 195.5 kb | Distal (>10kb) Multiome HiCAR | 430 | |
| chr2:20,650,354–20,651,898 | 204.1 kb | Distal (>10kb) Multiome HiCAR | 916 |
Genomic view of the RHOB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.