This gene encodes one of two non-erythroid members of the Rhesus (Rh) protein family. Non-erythroid Rh protein family members are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. All Rh family proteins are predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for RHBG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHBG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHBG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:156,076,488–156,077,355 | 292.2 kb | Distal (>10kb) Multiome | 246 | |
| chr1:156,081,942–156,083,586 | 286.6 kb | Distal (>10kb) Multiome | 670 | |
| chr1:156,105,879–156,107,316 | 262.6 kb | Distal (>10kb) Multiome | 663 | |
| chr1:156,114,184–156,115,669 | 254.6 kb | Distal (>10kb) Multiome | 824 | |
| chr1:156,123,520–156,124,091 | 245.5 kb | Distal (>10kb) Multiome | 679 | |
| chr1:156,129,945–156,130,610 | 238.9 kb | Distal (>10kb) Multiome | 733 | |
| chr1:156,149,593–156,150,242 | 219.2 kb | Distal (>10kb) Multiome | 194 | |
| chr1:156,160,602–156,161,218 | 208.1 kb | Distal (>10kb) Multiome | 218 | |
| chr1:156,181,487–156,182,119 | 187.4 kb | Distal (>10kb) Multiome | 145 | |
| chr1:156,193,531–156,194,375 | 175.3 kb | Distal (>10kb) Multiome | 751 | |
| chr1:156,212,611–156,213,686 | 156.1 kb | Distal (>10kb) Multiome | 893 | |
| chr1:156,245,413–156,246,269 | 123.5 kb | Distal (>10kb) Multiome | 380 | |
| chr1:156,282,165–156,283,323 | 86.5 kb | Distal (>10kb) Multiome | 973 | |
| chr1:156,291,233–156,291,857 | 77.7 kb | Distal (>10kb) Multiome | 518 | |
| chr1:156,337,825–156,339,056 | 30.8 kb | Distal (>10kb) Multiome | 836 | |
| chr1:156,356,873–156,357,393 | 12.1 kb | Distal (>10kb) Multiome | 506 | |
| chr1:156,368,893–156,369,552 | 25 bp | At TSS Multiome | 529 | |
| chr1:156,420,712–156,422,291 | 52.5 kb | Distal (>10kb) Multiome | 569 | |
| chr1:156,456,348–156,457,982 | 87.5 kb | Distal (>10kb) Multiome HiCAR | 1033 | |
| chr1:156,499,927–156,501,599 | 131.7 kb | Distal (>10kb) Multiome | 950 | |
| chr1:156,504,626–156,505,685 | 136.1 kb | Distal (>10kb) Multiome | 911 | |
| chr1:156,572,298–156,572,749 | 203.3 kb | Distal (>10kb) Multiome | 580 | |
| chr1:156,583,883–156,584,356 | 214.8 kb | Distal (>10kb) Multiome | 183 | |
| chr1:156,591,252–156,592,285 | 222.5 kb | Distal (>10kb) Multiome | 706 | |
| chr1:156,601,188–156,601,796 | 232.2 kb | Distal (>10kb) Multiome | 759 | |
| chr1:156,624,123–156,624,848 | 255.3 kb | Distal (>10kb) Multiome | 472 | |
| chr1:156,641,772–156,642,623 | 272.8 kb | Distal (>10kb) Multiome | 211 | |
| chr1:156,657,279–156,657,727 | 288.3 kb | Distal (>10kb) Multiome | 357 | |
| chr1:156,659,788–156,660,816 | 291.0 kb | Distal (>10kb) Multiome | 901 |
Genomic view of the RHBG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.